ecl-logo Documentation

Object[Protocol, MassSpectrometry]

Protocol for determining the mass of compounds by ionizing them and measuring their mass-to-charge ratio.

Organizational Information

    Name

    Name of this Object.
    Format: Single
    Class: String
    Programmatic Pattern: _String
    Pattern Description: A string.

    ID

    ID of this Object.
    Format: Single
    Class: String
    Programmatic Pattern: _String
    Pattern Description: The ID of this object.

    Object

    Object of this Object.
    Format: Single
    Class: Expression
    Programmatic Pattern: Object[Protocol, MassSpectrometry, _String]
    Pattern Description: The object reference of this object.

    Type

    Type of this Object.
    Format: Single
    Class: Expression

    Notebook

    Notebook this object belongs to.
    Format: Single
    Class: Link
    Programmatic Pattern: _Link
    Pattern Description: An object of that matches ObjectP[Object[LaboratoryNotebook]].

    Author

    The investigator who created this protocol.
    Format: Single
    Class: Link
    Programmatic Pattern: _Link

General

    DateConfirmed

    The date on which the protocol first entered processing or a backlog.
    Format: Single
    Class: Date
    Programmatic Pattern: _?DateObjectQ

    DateEnqueued

    The date on which the protocol was accepted and added to the queue.
    Format: Single
    Class: Date
    Programmatic Pattern: _?DateObjectQ

    DateStarted

    The date on which the protocol moved from the front of the queue to begin running in the lab.
    Format: Single
    Class: Date
    Programmatic Pattern: _?DateObjectQ

    DateCompleted

    The date on which the last step of this protocol's execution was finished.
    Format: Single
    Class: Date
    Programmatic Pattern: _?DateObjectQ

    DateCanceled

    The date on which the protocol was canceled and removed from the queue.
    Format: Single
    Class: Date
    Programmatic Pattern: _?DateObjectQ

    Script

    The script that created this protocol.
    Format: Single
    Class: Link
    Programmatic Pattern: _Link

    SubprotocolScripts

    All scripts generated by this protocol as a list of subprotocols.
    Format: Multiple
    Class: Link
    Programmatic Pattern: _Link

    Site

    The ECL site at which this protocol was executed.
    Format: Single
    Class: Link
    Programmatic Pattern: _Link

    SamplesIn

    Input samples for this analytical or preparative experiment.
    Format: Multiple
    Class: Link
    Programmatic Pattern: _Link

    ContainersIn

    Any containers containing this protocols' SamplesIn.
    Format: Multiple
    Class: Link
    Programmatic Pattern: _Link

    NumberOfReplicates

    Indicates the number of times the experiment is repeated with identical parameters.
    Format: Single
    Class: Integer
    Programmatic Pattern: GreaterP[0, 1]

    Status

    The current status of the protocol.
    Format: Single
    Class: Expression
    Programmatic Pattern: ProtocolStatusP

    CheckpointProgress

    A listing of all the checkpoints passed in the execution of this protocol.
    Format: Multiple

    [[1]] Name

      Header: Name
      Class: String
      Programmatic Pattern: _String

    [[2]] Start Time

      Header: Start Time
      Class: Date
      Programmatic Pattern: _?DateObjectQ

    [[3]] End Time

      Header: End Time
      Class: Date
      Programmatic Pattern: _?DateObjectQ|Null

    SubprotocolDescription

    A short title indicating what this subprotocol accomplishes.
    Format: Single
    Class: String
    Programmatic Pattern: _String

    BatchedUnitOperations

    The individual batches of the protocol, as they will be executed in the lab.
    Format: Multiple
    Class: Link
    Programmatic Pattern: _Link

    ReplacementProtocol

    If this protocol was aborted due to technical reasons, links to the replacement protocol run in its place.
    Format: Single
    Class: Link
    Programmatic Pattern: _Link

    Sterile

    Indicates if the protocol is performed in a sterile environment.
    Format: Single
    Class: Expression
    Programmatic Pattern: BooleanP

    LiquidHandlingLog

    The instrumentation trace file that monitored and recorded the execution of this robotic liquid handling.
    Format: Single
    Class: Link
    Programmatic Pattern: _Link

    PooledSamplesIn

    The members of SamplesIn gathered into the pools that are mixed in each AliquotContainer.
    Format: Multiple
    Class: Expression
    Programmatic Pattern: {ObjectReferenceP[Object[Sample]]..}

    NestedIndexMatchingSamplesIn

    The members of SamplesIn gathered into the pools that are mixed in each AliquotContainer.
    Format: Multiple
    Class: Expression
    Programmatic Pattern: {ObjectReferenceP[Object[Sample]]..}

    InitialNitrogenPressure

    The pressure data of the nitrogen gas source before starting the experiment.
    Format: Single
    Class: Link
    Programmatic Pattern: _Link

    NitrogenPressureLog

    The pressure log for the nitrogen gas source for the relevant section of the facility.
    Format: Single
    Class: Link
    Programmatic Pattern: _Link

    InitialCO2Pressure

    The pressure data of the CO2 gas source before starting the experiment.
    Format: Single
    Class: Link
    Programmatic Pattern: _Link

    CO2PressureLog

    The pressure log for the CO2 gas source for the relevant section of the facility.
    Format: Single
    Class: Link
    Programmatic Pattern: _Link

    InitialArgonPressure

    The pressure data of the argon gas source before starting the experiment.
    Format: Single
    Class: Link
    Programmatic Pattern: _Link

    HoldOrder

    Indicates if the queue position of this protocol should be strictly enforced, regardless of the available resources in the lab.
    Format: Single
    Class: Boolean
    Programmatic Pattern: BooleanP

    Priority

    Indicates if this protocol should be prioritized to start at the given StartDate, have dedicated operation for its entirety, and not be interrupted by other protocols.
    Format: Single
    Class: Boolean
    Programmatic Pattern: BooleanP

    StartDate

    The date at which this protocol should be prioritized to start.
    Format: Single
    Class: Date
    Programmatic Pattern: _?DateObjectQ

    Branch

    The git branch that this protocol should be run on.
    Format: Single
    Class: String
    Programmatic Pattern: _String

    Detectors

    Indicates the types of measurements performed for the experiment and available on the Instrument.
    Format: Multiple
    Class: Expression
    Programmatic Pattern: ChromatographyDetectorTypeP

    AcquisitionModes

    For each member of SamplesIn, the type of acquisition being performed in this protocol. MS mode measures the masses of the intact analytes, whereas MSMS measures the masses of the analytes fragmented by collision-induced dissociation.
    Format: Multiple
    Class: Expression
    Programmatic Pattern: AcquisitionModeP

    MassAnalyzer

    The type of the component of the mass spectrometer that performs ion separation based on m/z (mass-to-charge ratio).
    Format: Single
    Class: Expression
    Programmatic Pattern: MassAnalyzerTypeP

    Instrument

    The instrument used to perform the mass spectrometry experiment.
    Format: Single
    Class: Link
    Programmatic Pattern: _Link

    IntegratedHPLC

    The HPLC system that is coupled to the mass spectrometer instrument used for this experiment.
    Format: Single
    Class: Link
    Programmatic Pattern: _Link

    IonModes

    For each member of SamplesIn, indicates if positively or negatively charged ions are analyzed.
    Format: Multiple
    Class: Expression
    Programmatic Pattern: IonModeP

    IonSource

    The type of ionization used to create gas phase ions from the molecules in the sample. Electrospray ionization (ESI) produces ions using an electrospray in which a high voltage is applied to a liquid to create an aerosol, and gas phase ions are formed from the fine spray of charged droplets as a result of solvent evaporation and Coulomb fission. In matrix-assisted laser desorption/ionization (MALDI), the sample is embedded in a laser energy absorbing matrix which is then irradiated with a pulsed laser, ablating and desorbing the molecules with minimal fragmentation and creating gas phase ions from the analyte molecules in the sample.
    Format: Single
    Class: Expression
    Programmatic Pattern: IonSourceP

    InjectionType

    The type of injection used to inject the sample into the mass spectrometer. In DirectInfusion, the sample is directly injected into the instrument using the built-in fluidics pump system of the mass spectrometer without the use of any mobile phase. FlowInjection works by injecting the sample into a flowing solvent stream using a liquid chromatography autosampler and pumps, in the absence of chromatographic separation.
    Format: Single
    Class: Expression
    Programmatic Pattern: InjectionTypeP

    Buffer

    The solvent pumped through the flow path, carrying the sample through the ionization source and into the mass spectrometer.
    Format: Single
    Class: Link
    Programmatic Pattern: _Link

    InitialBufferVolume

    The volume of Buffer immediately before the experiment was started.
    Format: Single
    Class: Real
    Unit: 1 liter
    Programmatic Pattern: GreaterEqualP[0 Liter]

    InitialBufferAppearance

    An image of Buffer taken immediately before the experiment was started.
    Format: Single
    Class: Link
    Programmatic Pattern: _Link

    MethodFiles

    Method files used to conduct the mass spectrometry measurement of all SamplesIn zipped into one directory.
    Format: Single
    Class: Link
    Programmatic Pattern: _Link

    ScanModes

    For each member of SamplesIn, the mass scan mode for using in tandem mass analysis (ESI-QQQ).
    Format: Multiple
    Class: Expression
    Programmatic Pattern: MassSpecScanModeP

Replicate Experiments

    Template

    The protocol whose option selections should be selected as the default options for this protocol.
    Format: Single
    Class: Link
    Programmatic Pattern: _Link

    ProtocolsTemplated

    Protocols which were generated using this protocol's options as a starting point for its option defaults.
    Format: Multiple
    Class: Link
    Programmatic Pattern: _Link

Sample Preparation

    PreparatoryUnitOperations

    A list of transfers, consolidations, aliquots, mixes and dilutions that will be performed in the order listed to prepare samples for the experiment.
    Format: Multiple
    Class: Expression
    Programmatic Pattern: _ | _

    PreparatoryPrimitives

    A list of transfers, consolidations, aliquots, mixes and dilutions that will be performed in the order listed to prepare samples for the experiment.
    Format: Multiple
    Class: Expression
    Programmatic Pattern: _ | _

    VolumeCheckSamplePrep

    Indicates if any liquid samples prepared by using the PreparatoryUnitOperations option should have their volumes measured and updated before running the experiment.
    Format: Single
    Class: Expression
    Programmatic Pattern: BooleanP

    IncubateSamplePreparation

    For each member of SamplesIn, parameters describing how the input samples should be heated prior to any aliquoting or the start of the experiment.
    Format: Multiple

    [Incubate]

      Header: Incubate
      Class: Boolean

    [IncubationTemperature]

      Header: IncubationTemperature
      Class: Real
      Unit: 1 degree Celsius

    [IncubationTime]

      Header: IncubationTime
      Class: Real
      Unit: 1 second

    [Mix]

      Header: Mix
      Class: Boolean

    [MixType]

      Header: MixType
      Class: Expression

    [MixUntilDissolved]

      Header: MixUntilDissolved
      Class: Boolean

    [MaxIncubationTime]

      Header: MaxIncubationTime
      Class: Real
      Unit: 1 second

    [IncubationInstrument]

    [AnnealingTime]

      Header: AnnealingTime
      Class: Real
      Unit: 1 second

    [IncubateAliquotContainer]

      Header: IncubateAliquotContainer
      Class: Expression

    [IncubateAliquot]

      Header: IncubateAliquot
      Class: Real
      Unit: 1 liter

    [IncubateAliquotDestinationWell]

      Header: IncubateAliquotDestinationWell
      Class: Expression

    CentrifugeSamplePreparation

    For each member of SamplesIn, parameters describing how the input samples should be spun down prior to any aliquoting or the start of the experiment.
    Format: Multiple

    [Centrifuge]

      Header: Centrifuge
      Class: Boolean

    [CentrifugeInstrument]

    [CentrifugeIntensity]

      Header: CentrifugeIntensity
      Class: VariableUnit

    [CentrifugeTime]

      Header: CentrifugeTime
      Class: Real
      Unit: 1 minute

    [CentrifugeTemperature]

      Header: CentrifugeTemperature
      Class: Real
      Unit: 1 degree Celsius

    [CentrifugeAliquotContainer]

      Header: CentrifugeAliquotContainer
      Class: Expression

    [CentrifugeAliquot]

      Header: CentrifugeAliquot
      Class: Real
      Unit: 1 liter

    [CentrifugeAliquotDestinationWell]

      Header: CentrifugeAliquotDestinationWell
      Class: Expression

    FilterSamplePreparation

    For each member of SamplesIn, parameters describing how particulates should be separated from the input samples prior to any aliquoting or the start of the experiment.
    Format: Multiple

    [Filtration]

      Header: Filtration
      Class: Boolean

    [FiltrationType]

      Header: FiltrationType
      Class: Expression

    [Filter]

    [FilterMaterial]

      Header: FilterMaterial
      Class: Expression

    [FilterPoreSize]

      Header: FilterPoreSize
      Class: Real
      Unit: 1 micrometer

    [FilterContainerOut]

      Header: FilterContainerOut
      Class: Expression

    [FilterInstrument]

    [FilterSyringe]

    [FilterHousing]

    [FilterIntensity]

      Header: FilterIntensity
      Class: VariableUnit

    [FilterTime]

      Header: FilterTime
      Class: Real
      Unit: 1 minute

    [FilterTemperature]

      Header: FilterTemperature
      Class: Real
      Unit: 1 degree Celsius

    [FilterSterile]

      Header: FilterSterile
      Class: Boolean

    [FilterAliquotContainer]

      Header: FilterAliquotContainer
      Class: Expression

    [FilterAliquot]

      Header: FilterAliquot
      Class: Real
      Unit: 1 liter

    [PrefilterMaterial]

      Header: PrefilterMaterial
      Class: Expression

    [PrefilterPoreSize]

      Header: PrefilterPoreSize
      Class: Real
      Unit: 1 micrometer

    [FilterAliquotDestinationWell]

      Header: FilterAliquotDestinationWell
      Class: Expression

    SamplePreparationProtocols

    Protocols used to mix, centrifuge, incubate, and filter the SamplesIn prior to starting the experiment.
    Format: Multiple
    Class: Link
    Programmatic Pattern: _Link

    PooledIncubateSample Preparation

    For each member of PooledSamplesIn, parameters describing how the pooled samples should be incubated after aliquoting but prior to the start of the experiment.
    Format: Multiple

    [Incubate]

      Header: Incubate
      Class: Boolean

    [IncubationTemperature]

      Header: IncubationTemperature
      Class: Real
      Unit: 1 degree Celsius

    [IncubationTime]

      Header: IncubationTime
      Class: Real
      Unit: 1 second

    [Mix]

      Header: Mix
      Class: Boolean

    [MixType]

      Header: MixType
      Class: Expression

    [MixUntilDissolved]

      Header: MixUntilDissolved
      Class: Boolean

    [MaxIncubationTime]

      Header: MaxIncubationTime
      Class: Real
      Unit: 1 second

    [IncubationInstrument]

    [AnnealingTime]

      Header: AnnealingTime
      Class: Real
      Unit: 1 second

    [IncubateAliquotContainer]

      Header: IncubateAliquotContainer
      Class: Expression

    [IncubateAliquot]

      Header: IncubateAliquot
      Class: Real
      Unit: 1 liter

    [IncubateAliquotDestinationWell]

      Header: IncubateAliquotDestinationWell
      Class: Expression

    NestedIndexMatchingIncubate SamplePreparation

    For each member of NestedIndexMatchingSamplesIn, parameters describing how the pooled samples should be incubated after aliquoting but prior to the start of the experiment.
    Format: Multiple

    [Incubate]

      Header: Incubate
      Class: Boolean

    [IncubationTemperature]

      Header: IncubationTemperature
      Class: Real
      Unit: 1 degree Celsius

    [IncubationTime]

      Header: IncubationTime
      Class: Real
      Unit: 1 second

    [Mix]

      Header: Mix
      Class: Boolean

    [MixType]

      Header: MixType
      Class: Expression

    [MixUntilDissolved]

      Header: MixUntilDissolved
      Class: Boolean

    [MaxIncubationTime]

      Header: MaxIncubationTime
      Class: Real
      Unit: 1 second

    [IncubationInstrument]

    [AnnealingTime]

      Header: AnnealingTime
      Class: Real
      Unit: 1 second

    [IncubateAliquotContainer]

      Header: IncubateAliquotContainer
      Class: Expression

    [IncubateAliquot]

      Header: IncubateAliquot
      Class: Real
      Unit: 1 liter

    [IncubateAliquotDestinationWell]

      Header: IncubateAliquotDestinationWell
      Class: Expression

    PooledCentrifugeSample Preparation

    For each member of PooledSamplesIn, parameters describing how the pooled samples should be centrifuge after aliquoting and pooled mixing but prior to the start of the experiment.
    Format: Multiple

    [Centrifuge]

      Header: Centrifuge
      Class: Boolean

    [CentrifugeInstrument]

    [CentrifugeIntensity]

      Header: CentrifugeIntensity
      Class: VariableUnit

    [CentrifugeTime]

      Header: CentrifugeTime
      Class: Real
      Unit: 1 minute

    [CentrifugeTemperature]

      Header: CentrifugeTemperature
      Class: Real
      Unit: 1 degree Celsius

    [CentrifugeAliquotContainer]

      Header: CentrifugeAliquotContainer
      Class: Expression

    [CentrifugeAliquot]

      Header: CentrifugeAliquot
      Class: Real
      Unit: 1 liter

    [CentrifugeAliquotDestinationWell]

      Header: CentrifugeAliquotDestinationWell
      Class: Expression

    NestedIndexMatchingCentrifuge SamplePreparation

    For each member of PooledSamplesIn, parameters describing how the pooled samples should be centrifuge after aliquoting and pooled mixing but prior to the start of the experiment.
    Format: Multiple

    [Centrifuge]

      Header: Centrifuge
      Class: Boolean

    [CentrifugeInstrument]

    [CentrifugeIntensity]

      Header: CentrifugeIntensity
      Class: VariableUnit

    [CentrifugeTime]

      Header: CentrifugeTime
      Class: Real
      Unit: 1 minute

    [CentrifugeTemperature]

      Header: CentrifugeTemperature
      Class: Real
      Unit: 1 degree Celsius

    [CentrifugeAliquotContainer]

      Header: CentrifugeAliquotContainer
      Class: Expression

    [CentrifugeAliquot]

      Header: CentrifugeAliquot
      Class: Real
      Unit: 1 liter

    [CentrifugeAliquotDestinationWell]

      Header: CentrifugeAliquotDestinationWell
      Class: Expression

    FilteredSamples

    Samples corresponding to filtered eluents of SamplesIn generated during sample preparation and intended for use in this experiment.
    Format: Multiple
    Class: Link
    Programmatic Pattern: _Link
    Relation: Object[Sample]

    MALDIPlate

    The plate containing the spots of sample and calibrant embedded in laser energy absorbing matrix for matrix-assisted laser desorption/ionization (MALDI) analysis.
    Format: Single
    Class: Link
    Programmatic Pattern: _Link

    Calibrants

    For each member of SamplesIn, a sample with known m/z (mass-to-charge ratios) used to calibrate the mass spectrometer.
    Format: Multiple
    Class: Link
    Programmatic Pattern: _Link

    Matrices

    For each member of SamplesIn, the matrix co-spotted with the sample to assist in ionization.
    Format: Multiple
    Class: Link
    Programmatic Pattern: _Link

    CalibrantMatrices

    For each member of SamplesIn, the calibrant matrix co-spotted with the calibrant to assist in ionization.
    Format: Multiple
    Class: Link
    Programmatic Pattern: _Link

    SpottingMethods

    For each member of SamplesIn, the layering technique used to spot the MALDI plate with sample and matrix.
    Format: Multiple
    Class: Expression
    Programmatic Pattern: SpottingMethodP

    SpottingPattern

    Indicates if all wells can be spotted (All) or if every other well is spotted (Spaced) to avoid contamination.
    Format: Single
    Class: Expression
    Programmatic Pattern: SpottingPatternP

    SpottingInstrument

    The liquid handler used to spot the MALDI plate.
    Format: Single
    Class: Link
    Programmatic Pattern: _Link

    MixProtocols

    The mix protocols used to mix the source samples prior to use in the experiment.
    Format: Multiple
    Class: Link
    Programmatic Pattern: _Link

    SpottingDryTime

    The amount of time the samples are left to dry after they have been aliquoted onto the MALDI plate.
    Format: Single
    Class: Real
    Unit: 1 second
    Programmatic Pattern: GreaterEqualP[0 Second]

    SampleVolumes

    For each member of SamplesIn, the volume taken from the sample and aliquoted onto the MALDI plate (in MALDI mass spectrometry) or injected into the mass spectrometer (in ESI mass spectrometry).
    Format: Multiple
    Class: Real
    Unit: 1 microliter
    Programmatic Pattern: GreaterP[0 Microliter]

    MALDIPlatePrep

    A sample manipulation protocol used to transfer samples, matrices and calibrants onto the MALDI plate.
    Format: Single
    Class: Link
    Programmatic Pattern: _Link

    PlateSeal

    The package of pierceable, adhesive film used to cover plates of injection samples in this experiment in order to mitigate sample evaporation.
    Format: Single
    Class: Link
    Programmatic Pattern: _Link

    SampleTemperature

    The nominal temperature of the autosampler where the input samples are incubated prior to injection into the mass spectrometer.
    Format: Single
    Class: Real
    Unit: 1 degree Celsius
    Programmatic Pattern: GreaterEqualP[0 Kelvin]

Aliquoting

    AliquotSamplePreparation

    For each member of AliquotSamples, parameters describing how aliquots should be drawn from the input samples after initial sample preparation in order to create new aliquot samples upon which aliquot preparation and the experiment should proceed.
    Format: Multiple

    [Aliquot]

      Header: Aliquot
      Class: Boolean

    [AliquotAmount]

      Header: AliquotAmount
      Class: Expression

    [TargetConcentration]

      Header: TargetConcentration
      Class: Expression

    [AssayVolume]

      Header: AssayVolume
      Class: Real
      Unit: 1 milliliter

    [AliquotContainer]

      Header: AliquotContainer
      Class: Expression

    [AssayBuffer]

    [BufferDiluent]

    [BufferDilutionFactor]

      Header: BufferDilutionFactor
      Class: Real

    [ConcentratedBuffer]

    [DestinationWell]

      Header: DestinationWell
      Class: Expression

    [TargetConcentrationAnalyte]

      Header: TargetConcentrationAnalyte
      Class: Expression

    [AliquotSampleLabel]

      Header: AliquotSampleLabel
      Class: String

    AliquotProtocols

    Protocols used to create AliquotSamples prior to starting the experiment.
    Format: Multiple
    Class: Link
    Programmatic Pattern: _Link

    AliquotPreparationProtocols

    Protocols used to mix, centrifuge, incubate, and filter the AliquotSamples prior to starting the experiment.
    Format: Multiple
    Class: Link
    Programmatic Pattern: _Link

    AliquotSamples

    Samples corresponding to aliquots of SamplesIn generated during sample preparation and intended for use in this experiment.
    Format: Multiple
    Class: Link
    Programmatic Pattern: _Link
    Relation: Object[Sample]

    AliquotContainers

    Containers that hold AliquotSamples generated during sample preparation and intended for use in this experiment.
    Format: Multiple
    Class: Link
    Programmatic Pattern: _Link

    SaveAliquots

    Indicates if the AliquotSamples should be stored after the experiment, rather than being discarded.
    Format: Single
    Class: Expression
    Programmatic Pattern: BooleanP

    ConsolidateAliquots

    Indicates if identical aliquots should be consolidated in a single sample.
    Format: Single
    Class: Expression
    Programmatic Pattern: BooleanP

    AliquotPreparation

    Indicates if the aliquotting should occur manually or on a robotic liquid handler.
    Format: Single
    Class: Expression
    Programmatic Pattern: PreparationMethodP

    AliquotVolumes

    For each member of SamplesIn, the volume transferred from the sample into the aliquot sample which is used in lieu of the initial sample for the experiment.
    Format: Multiple
    Class: Real
    Unit: 1 microliter
    Programmatic Pattern: GreaterP[0 Micro Liter]

    AliquotMasses

    For each member of SamplesIn, the mass of a solid transferred from the sample into the aliquot sample which is used in lieu of the initial sample for the experiment.
    Format: Multiple
    Class: Real
    Unit: 1 milligram
    Programmatic Pattern: GreaterP[0 Milligram]

    AliquotAmounts

    For each member of SamplesIn, the amount transferred from the sample into the aliquot sample which is used in lieu of the initial sample for the experiment.
    Format: Multiple
    Class: VariableUnit
    Programmatic Pattern: GreaterP[0 Milliliter] | GreaterP[0 Milligram] | GreaterP[0 Unit, 1 Unit]

    TargetConcentrations

    For each member of SamplesIn, the final concentration of analyte in the aliquot sample which is used in lieu of the initial sample for the experiment.
    Format: Multiple
    Class: Expression
    Programmatic Pattern: Milligram Hold[GreaterP[0 Micro Molar] | GreaterP[0 ----------]] Milliliter

    AssayVolumes

    For each member of SamplesIn (or PooledSamplesIn), the total volume of the reaction mixture which is used in lieu of the initial sample for the experiment.
    Format: Multiple
    Class: Real
    Unit: 1 microliter
    Programmatic Pattern: GreaterEqualP[0 Micro Liter]

    AssayBuffers

    For each member of SamplesIn (or PooledSamplesIn), the final buffers used to generate AliquotSamples by aliquoting SamplesIn.
    Format: Multiple
    Class: Link
    Programmatic Pattern: _Link

    ConcentratedBuffers

    For each member of SamplesIn (or PooledSamplesIn), the concentrated buffer source which is added to the AliquotSamples to obtain 1x buffer concentration after dilution of the AliquotSamples which are used in lieu of the SamplesIn for the experiment.
    Format: Multiple
    Class: Link
    Programmatic Pattern: _Link

    BufferDilutionFactors

    For each member of SamplesIn (or PooledSamplesIn), he dilution factor by which the concentrated buffer is diluted in preparing the AliquotSamples to obtain a 1x buffer concentration after dilution of the AliquotSamples which are used in lieu of the SamplesIn for the experiment.
    Format: Multiple
    Class: Real
    Programmatic Pattern: GreaterP[0]

    BufferDiluents

    For each member of SamplesIn (or PooledSamplesIn), the diluent used to dilute the concentration of the concentrated buffer in preparing the AliquotSamples which are used in lieu of the SamplesIn for the experiment.
    Format: Multiple
    Class: Link
    Programmatic Pattern: _Link

    ConcentratedBuffer

    The concentrated buffer source which is added to each of the AliquotSamples to obtain 1x buffer concentration after dilution of the AliquotSamples which are used in lieu of the SamplesIn for the experiment.
    Format: Single
    Class: Link
    Programmatic Pattern: _Link

    BufferDilutionFactor

    The dilution factor by which the concentrated buffer is diluted in preparing the AliquotSamples to obtain a 1x buffer concentration after dilution of the AliquotSamples which are used in lieu of the SamplesIn for the experiment.
    Format: Single
    Class: Integer
    Programmatic Pattern: GreaterP[0]

    BufferDiluent

    The diluent used to dilute the concentration of the concentrated buffer in preparing the AliquotSamples which are used in lieu of the SamplesIn for the experiment.
    Format: Single
    Class: Link
    Programmatic Pattern: _Link

    AssayBuffer

    The desired buffer for the AliquotSamples which are used in lieu of the SamplesIn for the experiment.
    Format: Single
    Class: Link
    Programmatic Pattern: _Link

Sample Post-Processing

    PostProcessingProtocols

    Protocols used to perform post-processing such as sample imaging or volume measurement.
    Format: Multiple
    Class: Link
    Programmatic Pattern: _Link

    ImageSample

    Indicates if the samples that are modified in the course of the experiment are imaged after running the experiment.
    Format: Single
    Class: Expression
    Programmatic Pattern: BooleanP

    MeasureVolume

    Indicates if the volume of the liquid samples modified in the course of the experiment are measured after running the experiment.
    Format: Single
    Class: Expression
    Programmatic Pattern: BooleanP

    MeasureWeight

    Indicates if the weight of the solid samples modified in the course of the experiment are measured after running the experiment.
    Format: Single
    Class: Expression
    Programmatic Pattern: BooleanP

    Measure

    Indicates if the volume/weight of the samples modified in the course of the experiment are measured after running the experiment.
    Format: Single
    Class: Expression
    Programmatic Pattern: BooleanP

    Storage

    Indicates the conditions under which any samples generated by this experiment are stored after the protocol is completed.
    Format: Single
    Class: Expression
    Programmatic Pattern: SampleStorageTypeP | Disposal

Experimental Results

    Data

    Any primary data generated by this protocol.
    Format: Multiple
    Class: Link
    Programmatic Pattern: _Link

    SamplesOut

    Any preparative samples generated by the protocol.
    Format: Multiple
    Class: Link
    Programmatic Pattern: _Link

    ContainersOut

    Any containers holding SamplesOut generated by this protocol.
    Format: Multiple
    Class: Link
    Programmatic Pattern: _Link

    EnvironmentalData

    Measurements of environmental conditions (temperature and humidity) recorded during the execution of this protocol.
    Format: Multiple
    Class: Link
    Programmatic Pattern: _Link

    RawDataFiles

    The raw data (in .raw Waters format) pertaining to the mass spectrometry measurement of all SamplesIn zipped into one directory.
    Format: Single
    Class: Link
    Programmatic Pattern: _Link

    CalibrantData

    Mass spectra of calibrants used in this protocol.
    Format: Multiple
    Class: Link
    Programmatic Pattern: _Link

    MatrixData

    Mass spectra for matrices used in this protocol.
    Format: Multiple
    Class: Link
    Programmatic Pattern: _Link

Troubleshooting

    TroubleshootingReports

    Reports for errors that require troubleshooting associated with the execution of this top-level protocol.
    Format: Multiple
    Class: Link
    Programmatic Pattern: _Link

Resources

    AwaitingResources

    Indicates if this protocol is awaiting the arrival of items before it can be begun or continued.
    Format: Single
    Class: Boolean
    Programmatic Pattern: BooleanP

    ShippingMaterials

    Indicates the transactions, and the specific products or samples therein, that must be received before this protocol can be begun or continued.
    Format: Multiple

    [[1]] Transaction

    [[2]] Required Product

    HazardousWaste

    The types of waste generated by this protocol.
    Format: Multiple
    Class: Link
    Programmatic Pattern: _Link

    DispenserContainers

    Containers gathered as destinations for any resources obtained from a chemical dispenser.
    Format: Multiple
    Class: Link
    Programmatic Pattern: _Link

    GasSources

    A list of containers that supplied gas to instruments in this protocol through plumbing connections.
    Format: Multiple

    [[1]] Gas Type

      Header: Gas Type
      Class: Expression
      Programmatic Pattern: GasP

    [[2]] Source Container

      Header: Source Container
      Class: Link
      Programmatic Pattern: _Link

    [[3]] Supplied Instrument

      Header: Supplied Instrument
      Class: Link
      Programmatic Pattern: _Link

Cleaning

    WasteGenerated

    For each type of waste generated by this protocol, the total amount (in grams) generated during the conduct of the protocol.
    Format: Multiple

    [Waste]

    [Weight]

      Header: Weight
      Class: Real
      Unit: 1 gram

    NeedleWashSolution

    The solution used to wash the exterior of the injection needle before, during, and after the experiment.
    Format: Single
    Class: Link
    Programmatic Pattern: _Link

    TubingRinseSolution

    The solution used to rinse buffers lines before and after and the experiment.
    Format: Single
    Class: Link
    Programmatic Pattern: _Link

Storage Information

    StoragePrice

    The total monthly price for warehousing all user owned items associated with this protocol in an ECL facility under the storage conditions specified by each item.
    Format: Single
    Class: Real
    Unit: 1 US dollar per month
    Programmatic Pattern: USD Hold[GreaterEqualP[0 -----]] Month

Sample Storage

    SamplesInStorage

    For each member of SamplesIn, The storage conditions under which any input samples to this experiment should be stored after their usage in this experiment.
    Format: Multiple
    Class: Expression
    Programmatic Pattern: SampleStorageTypeP | Disposal

    AliquotStorage

    For each member of AliquotSamples, The storage conditions under which any aliquot samples generated by this experiment should be stored after the protocol is completed.
    Format: Multiple
    Class: Expression
    Programmatic Pattern: SampleStorageTypeP | Disposal

    SamplesOutStorage

    For each member of SamplesOut, the storage conditions under which any output samples generated by this experiment should be stored after the protocol is completed.
    Format: Multiple
    Class: Expression
    Programmatic Pattern: SampleStorageTypeP | Disposal

    CalibrantStorage

    For each member of Calibrants, The storage conditions under which any input samples to this experiment should be stored after their usage in this experiment.
    Format: Multiple
    Class: Expression
    Programmatic Pattern: SampleStorageTypeP | Disposal

Option Handling

    ResolvedOptions

    The final options used as parameters for this protocol, after automatic options are resolved.
    Format: Single
    Class: Compressed
    Programmatic Pattern: {_Rule...}

    UnresolvedOptions

    The verbatim options originally input by the protocol author to generate this protocol, often with some options set to Automatic.
    Format: Single
    Class: Compressed
    Programmatic Pattern: {_Rule...}

Computations

    ParallelComputations

    List of computational jobs generated and run in parallel to the execution of this protocol.
    Format: Multiple
    Class: Link
    Programmatic Pattern: _Link

    ComputationsOutstanding

    Indicates if any of the computation jobs in ParallelComputations have not yet completed.
    Format: Single
    Class: Boolean
    Programmatic Pattern: BooleanP

    ErroneousComputations

    List of computational jobs generated and run in parallel to the execution of this protocol in which a warning or error was thown, or that did not finish.
    Format: Multiple
    Class: Link
    Programmatic Pattern: _Link

Ionization

    SourceTemperatures

    For each member of SamplesIn, the temperature that the source block is set to in order to discourage condensation and decrease solvent clustering in the reduced vacuum region of the source. The source block is the metallic chamber with reduced pressure separating the sprayer (at atmospheric pressure) and the inside of the mass spectrometer (at 10^-7 Torr of pressure). It consists of the sampling cone, the isolation valve, and the ion block. The source temperature setting affects sensitivity and is adjusted according to InfusionFlowRates (the higher the flow rate, the higher the temperature).
    Format: Multiple
    Class: Real
    Unit: 1 degree Celsius
    Programmatic Pattern: GreaterP[0 Celsius]

    DesolvationTemperatures

    For each member of SamplesIn, the temperature setting for the ESI (electrospray ionization) desolvation heater that controls the nitrogen gas temperature used for solvent cluster evaporation, in order to produce single gas phase ions from the ion spray. This temperature setting affects sensitivity and is usually adjusted according to InfusionFlowRates (the higher the flow rate, the higher the temperature). Please refer to the documentation for details.
    Format: Multiple
    Class: Real
    Unit: 1 degree Celsius
    Programmatic Pattern: GreaterP[0 Celsius]

    ESICapillaryVoltages

    For each member of SamplesIn, the absolute voltage applied to the tip of the stainless steel ESI (electrospray ionization) capillary tubing in order to produce charged droplets.
    Format: Multiple
    Class: Real
    Unit: 1 volt
    Programmatic Pattern: UnitsP[0 Volt]

    DesolvationGasFlows

    For each member of SamplesIn, the nitrogen gas flow ejected around the ESI (electrospray ionization) capillary, used for solvent evaporation to produce single gas phase ions from the ion spray. This setting affects sensitivity and is usually adjusted according to InfusionFlowRates (the higher the flow rate, the higher the desolvation gas flow). Please refer to the documentation for details.
    Format: Multiple
    Class: VariableUnit
    Programmatic Pattern: 1 Liter Hold[GreaterP[-------] | GreaterP[0 PSI]] Hour

    ConeGasFlows

    For each member of SamplesIn, the nitrogen gas flow ejected around the sample inlet cone (the spherical metal plate on the source block, acting as a first gate between the sprayer and the reduced-pressure ion block). This gas flow is used to minimize the formation of solvent ion clusters. It also helps reduce adduct ions and directing the spray into the ion block while keeping the sample cone clean.
    Format: Multiple
    Class: VariableUnit
    Programmatic Pattern: 1 Liter Hold[GreaterP[-------] | GreaterP[0 PSI]] Hour

    StepwaveVoltages

    For each member of SamplesIn, the absolute voltage applied to the tip of the stainless steel ESI (electrospray ionization) capillary tubing in order to produce charged droplets.
    Format: Multiple
    Class: Real
    Unit: 1 volt
    Programmatic Pattern: GreaterP[0 Volt]

    IonGuideVoltages

    For each member of SamplesIn, the absolute voltage applied to the tip of the stainless steel ESI (electrospray ionization) capillary tubing in order to produce charged droplets. This option is diagrammed as IonSprayVoltage for ESI-QQQ.
    Format: Multiple
    Class: Real
    Unit: 1 volt
    Programmatic Pattern: UnitsP[0 Volt]

    DeclusteringVoltages

    For each member of SamplesIn, the voltage offset between the 1st and 2nd stage of the stepwave ion guide which leads ions coming from the sample cone (the metal shield covering the front of the source block), towards the quadrupole mass analyzer. For ESI-QTOF this was also known as SourceVoltageOffsets. This option also know as Sampling Cone Voltages and Declustering Potential (DP).
    Format: Multiple
    Class: Real
    Unit: 1 volt
    Programmatic Pattern: UnitsP[0 Volt]

    MinLaserPowers

    For each member of SamplesIn, the minimum laser power used to collect mass spectrometry data for the sample.
    Format: Multiple
    Class: Real
    Unit: 1 percent
    Programmatic Pattern: RangeP[0 Percent, 100 Percent]

    MaxLaserPowers

    For each member of SamplesIn, the maximum laser power used to collect mass spectrometry data for the sample.
    Format: Multiple
    Class: Real
    Unit: 1 percent
    Programmatic Pattern: RangeP[0 Percent, 100 Percent]

    ShotsPerRaster

    The number of repeated shots between each raster movement within a well.
    Format: Single
    Class: Integer
    Programmatic Pattern: GreaterP[0, 1]

    NumberOfShots

    The number of times the mass spectrometer fires the laser to collect this mass spectrometry data.
    Format: Single
    Class: Integer
    Programmatic Pattern: GreaterP[0, 1]

    DelayTimes

    For each member of SamplesIn, the delay between laser ablation and ion extraction accepted by the instrument.
    Format: Multiple
    Class: Real
    Unit: 1 nanosecond
    Programmatic Pattern: GreaterEqualP[0 Second]

    Gains

    For each member of SamplesIn, the signal amplification factor applied to the detector.
    Format: Multiple
    Class: Real
    Programmatic Pattern: RangeP[1, 10]

    LaserFrequency

    The rate at which the mass spectrometer fires the laser onto the sample spots on the MALDI plate to create gas phase ions for mass analysis.
    Format: Single
    Class: Real
    Unit: 1 hertz
    Programmatic Pattern: GreaterP[0 Hertz]

Mass Analysis

    MinMasses

    For each member of SamplesIn, the lowest value of the range of measured mass-to-charge ratio (m/z).
    Format: Multiple
    Class: Real
    Unit: 1 gram per mole
    Programmatic Pattern: 0 Gram Hold[GreaterEqualP[------]] Mole

    MaxMasses

    For each member of SamplesIn, the highest value of the range of measured mass-to-charge ratio (m/z).
    Format: Multiple
    Class: Real
    Unit: 1 gram per mole
    Programmatic Pattern: 0 Gram Hold[GreaterP[------]] Mole

    AcquisitionTime

    Length of time during which samples are being injected and their m/z signal is sampled and digitized.
    Format: Single
    Class: Real
    Unit: 1 second
    Programmatic Pattern: GreaterP[0 Second]

    InfusionSyringes

    For each member of SamplesIn, the syringe used in ESI-QQQ instrument for direct infusion the sample via syringe pump.
    Format: Multiple
    Class: Link
    Programmatic Pattern: _Link

    InfusionSyringeInnerDiameters

    For each member of SamplesIn, the inner diameter of the syringes that are supposed to be used on syringe pump.
    Format: Multiple
    Class: Real
    Unit: 1 millimeter
    Programmatic Pattern: GreaterP[0 Millimeter]

    InfusionSyringeNeedles

    For each member of SamplesIn, the needle used by the syringe in the DirectInfusion process used in ESI-QQQ instrument via syringe pump.
    Format: Multiple
    Class: Link
    Programmatic Pattern: _Link

    InfusionSyringeTubing

    The tubing we used to connect the syringe from the syring pump to the mass spectrometer.
    Format: Single
    Class: Link
    Programmatic Pattern: _Link
    Relation: Alternatives[Object[Plumbing, Tubing]]

    InfusionFlowRates

    For each member of SamplesIn, the speed at which the sample is being injected into the mass spectrometer.
    Format: Multiple
    Class: Real
    Unit: 1 microliter per minute
    Programmatic Pattern: Microliter Hold[GreaterP[0 ----------]] Minute

    InfusionVolumes

    For each member of SamplesIn, the volume of sample being injected into the mass spectrometer by using syringe pumps, this is a unique field of ESI-QQQ.
    Format: Multiple
    Class: Real
    Unit: 1 milliliter
    Programmatic Pattern: GreaterP[0 Milliliter]

    ScanTimes

    For each member of SamplesIn, the duration of time allowed to pass between each spectral acquisition.
    Format: Multiple
    Class: Real
    Unit: 1 second
    Programmatic Pattern: GreaterP[0 Second]

    RunDurations

    For each member of SamplesIn, the duration of time for which spectra are acquired for the sample currently being injected.
    Format: Multiple
    Class: Real
    Unit: 1 minute
    Programmatic Pattern: GreaterP[0 Minute]

    AccelerationVoltages

    For each member of SamplesIn, the voltage applied to the target plate to accelerate the ions.
    Format: Multiple
    Class: Real
    Unit: 1 kilovolt
    Programmatic Pattern: GreaterEqualP[0 Volt]

    GridVoltages

    For each member of SamplesIn, the voltage applied to the grid electrode.
    Format: Multiple
    Class: Real
    Unit: 1 kilovolt
    Programmatic Pattern: GreaterEqualP[0 Volt]

    LensVoltages

    For each member of SamplesIn, the voltage applied to the ion focusing lens located at the entrance of the mass analyser.
    Format: Multiple
    Class: Real
    Unit: 1 kilovolt
    Programmatic Pattern: GreaterEqualP[0 Volt]

    CalibrationMethods

    For each member of SamplesIn, the calibration settings used to calibrate the instrument.
    Format: Multiple
    Class: Link
    Programmatic Pattern: _Link
    Relation: Object[Method]

    CalibrantVolumes

    The volumes taken from calibrants and aliquoted onto the MALDI plate.
    Format: Multiple
    Class: Real
    Unit: 1 microliter
    Programmatic Pattern: GreaterP[0 Microliter]

    MassSelections

    For each member of SamplesIn, if the sample will be scan in tandem mass mode, this option represents the selected mass-to-charge ratio (m/z) value of the first mass analyzer in mass selection mode (MS1, Quadrupole for both ESI-QQQ).
    Format: Multiple
    Class: Expression
    Programmatic Pattern: 0 Gram 0 Gram Hold[{({GreaterP[------]..} | GreaterP[------] | Null)..}] Mole Mole

    FragmentMassSelections

    For each member of SamplesIn, if the sample will be scan in tandem mass mode, this option represents the selected mass-to-charge ratio (m/z) value of the first mass analyzer in mass selection mode (MS2, unique option for the 2nd Quadrupole of ESI-QQQ).
    Format: Multiple
    Class: Expression
    Programmatic Pattern: 0 Gram 0 Gram Hold[{({GreaterP[------]..} | GreaterP[------] | Null)..}] Mole Mole

    CollisionEnergies

    For each member of SamplesIn, if the sample will be scanned in tandem mass spectrometry mode, the value of the potential applied on collision cell to fragment the sample ions after passing MS1.
    Format: Multiple
    Class: Expression
    Programmatic Pattern: {({UnitsP[0 Volt]..} | UnitsP[0 Volt] | Null)..}

    FragmentMinMasses

    For each member of SamplesIn, if the sample will be scanned in tandem mass spectrometry mode, the lowest value of the range of measured mass-to-charge ratio (m/z)for the second mass analyzer (MS2, Qudrapole analyzer for QQQ and TimeOfFlight analyzer for QTOF).
    Format: Multiple
    Class: Real
    Unit: 1 gram per mole
    Programmatic Pattern: 0 Gram Hold[GreaterP[------]] Mole

    FragmentMaxMasses

    For each member of SamplesIn, if the sample will be scanned in tandem mass spectrometry mode, the highest value of the range of measured mass-to-charge ratio (m/z) for the second mass analyzer (MS2,Quadrapole analyzer for QQQ and Time-Of-Flight analyzer for QTOF).
    Format: Multiple
    Class: Real
    Unit: 1 gram per mole
    Programmatic Pattern: 0 Gram Hold[GreaterP[------]] Mole

    MassTolerances

    For each member of SamplesIn, if the sample will be scanned in tandem mass spectrometry mode, the value for the mass tolerance in MS1 and MS2 in mass scan mode, indicating the step size of both MS1 and MS2 when both or either one of them are set in mass selection mode. This value indicate the mass range used to find a peak with twice the entered range.
    Format: Multiple
    Class: Real
    Unit: 1 gram per mole
    Programmatic Pattern: 0 Gram Hold[GreaterP[------]] Mole

    CollisionCellExitVoltages

    For each member of SamplesIn, if the sample will be scanned in tandem mass spectrometry mode in ESI-QQQ, the value of the potential applied between collision cell and the second Quadrupole mass analyzer (MS2) to guide and focus the ion beam into MS2.
    Format: Multiple
    Class: Real
    Unit: 1 volt
    Programmatic Pattern: UnitsP[0 Volt]

    DwellTimes

    For each member of SamplesIn, if the sample will be scan in SelectedIonMonitoring mode or MultipleReactionMonitoring mode, the length of time for each mass selection or mass selection pairs.
    Format: Multiple
    Class: Expression
    Programmatic Pattern: {({GreaterP[0 Millisecond]..} | GreaterP[0 Millisecond] | Null)..}

    MultipleReactionMonitoring Assays

    For each member of SamplesIn, in ESI-QQQ, that firstly targets the ion corresponding to the compound of interest with subsequent fragmentation of that target ion to produce a range of daughter ions. One (or more) of these fragment daughter ions can be selected for quantitation purposes. Only compounds that meet both these criteria, i.e. specific parent ion and specific daughter ions corresponding to the mass of the molecule of interest are detected within the mass spectrometer. The mass assays (MS1/MS2 mass value combinations) for each scan, along with the CollisionEnergy and dwell time (length of time of each scan).
    Format: Multiple

    [MS1Mass]

      Header: MS1Mass
      Class: Expression

    [CollisionEnergy]

      Header: CollisionEnergy
      Class: Expression

    [MS2Mass]

      Header: MS2Mass
      Class: Expression

    [DwellTime]

      Header: DwellTime
      Class: Expression

    NeutralLosses

    For each member of SamplesIn, if the sample will be scanned in tandem mass spectrometry mode with Neutral Ion Loss mode, the value for the mass offset values between MS1 and MS2 (neutral ion loss value.).
    Format: Multiple
    Class: Real
    Unit: 1 gram per mole
    Programmatic Pattern: 0 Gram Hold[GreaterP[------]] Mole

Plate Cleaning

    Sonicator

    The sonicator used to clean the MALDI plate.
    Format: Single
    Class: Link
    Programmatic Pattern: _Link

    PrimaryPlateCleaningSolvent

    The initial solution used to clean the MALDI plate after the experimental run has completed.
    Format: Single
    Class: Link
    Programmatic Pattern: _Link

    SecondaryPlateCleaningSolvent

    The secondary solution used to remove any remaining material on the MALDI plate after the experimental run has completed.
    Format: Single
    Class: Link
    Programmatic Pattern: _Link
Last modified on Mon 26 Sep 2022 15:43:50